Induction of Cardiac Insulin-Like Growth Factor I Gene Expression in Pressure Overload Hypertrophy
作者： Mark C. Hanson , Kenneth A. Fath , R. Wayne Alexander , P. Delafontaine
DOI: 10.1097/00000441-199308000-00001
关键词: Ventricular pressure 、 Muscle hypertrophy 、 Insulin-like growth factor 、 Gene expression 、 Biology 、 Internal medicine 、 Growth factor 、 Pressure overload 、 Endocrinology 、 Somatomedin 、 Left ventricular hypertrophy
摘要: Molecular mechanisms regulating the cardiac hypertrophic response to increased hemodynamic load are understood poorly. Insulin-like growth factor I (IGF I) is a mitogen that is thought to play a key role in pre-and postnatal growth. To investigate a possible role of IGF I in the cardiac response to pressure overload, rats underwent banding of the ascending aorta immediately above the aortic valve using a hemoclip, or a sham procedure. An analysis of left-ventricular RNA by Northern hybridization using a 32 P-labeled IGF I cDNA …
sci-hub.se 参考文章(32)
P K Lund, B M Moats-Staats, M A Hynes, J G Simmons, M Jansen, A J D'Ercole, J J Van Wyk, Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues. Journal of Biological Chemistry. ,vol. 261, pp. 14539- 14544 ,(1986) , 10.1016/S0021-9258(18)66903-0
J. D. Turner, P. Rotwein, J. Novakofski, P. J. Bechtel, Induction of mRNA for IGF-I and -II during growth hormone-stimulated muscle hypertrophy American Journal of Physiology-endocrinology and Metabolism. ,vol. 255, ,(1988) , 10.1152/AJPENDO.1988.255.4.E513
B Cercek, M C Fishbein, J S Forrester, R H Helfant, J A Fagin, Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation. Circulation Research. ,vol. 66, pp. 1755- 1760 ,(1990) , 10.1161/01.RES.66.6.1755
P Delafontaine, K E Bernstein, R W Alexander, Insulin-like growth factor I gene expression in vascular cells. Hypertension. ,vol. 17, pp. 693- 699 ,(1991) , 10.1161/01.HYP.17.5.693
VICKI R. SARA, KERSTIN HALL, PER-ERIC LINS, LINDA FRYKLUND, Serum levels of immunoreactive somatomedin A in the rat: some developmental aspects. Endocrinology. ,vol. 107, pp. 622- 625 ,(1980) , 10.1210/ENDO-107-2-622
ALAN D. STILES, ILENE R. S. SOSENKO, A. JOSEPH D’ERCOLE, BARRY T. SMITH, Relation of kidney tissue somatomedin-c/insulin-like growth factor i to postnephrectomy renal growth in the rat Endocrinology. ,vol. 117, pp. 2397- 2401 ,(1985) , 10.1210/ENDO-117-6-2397
W L Lowe, M Adamo, H Werner, C T Roberts, D LeRoith, Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding. Journal of Clinical Investigation. ,vol. 84, pp. 619- 626 ,(1989) , 10.1172/JCI114207
Hans-Arne Hansson, Eva Jennische, Anna Skottner, Regenerating endothelial cells express insulin-like growth factor-I immunoreactivity after arterial injury. Cell and Tissue Research. ,vol. 250, pp. 499- 505 ,(1987) , 10.1007/BF00218940
VICTOR K. M. HAN, P. KAY LUND, DAVID C. LEE, JOSEPH D'ERCOLE, Expression of Somatomedin/Insulin-Like Growth Factor Messenger Ribonucleic Acids in the Human Fetus: Identification, Characterization, and Tissue Distribution* The Journal of Clinical Endocrinology and Metabolism. ,vol. 66, pp. 422- 429 ,(1988) , 10.1210/JCEM-66-2-422
A Joseph D'Ercole, David J Hill, Alastair J Strain, Louis E Underwood, Tissue and Plasma Somatomedin-C/Insulin-Like Growth Factor I Concentrations in the Human Fetus during the First Half of Gestation Pediatric Research. ,vol. 20, pp. 253- 255 ,(1986) , 10.1203/00006450-198603000-00011