HIV-1 Nef Enhances Dendritic Cell-Mediated Viral Transmission to CD4+ T Cells and Promotes T-Cell Activation
作者： Corine St. Gelais , Christopher M. Coleman , Jian-Hua Wang , Li Wu
DOI: 10.1371/JOURNAL.PONE.0034521
关键词:
摘要: HIV-1 Nef enhances dendritic cell (DC)-mediated viral transmission to CD4+ T cells, but the underlying mechanism is not fully understood. It also unknown whether infected DCs play a role in activating cells and enhancing DC-mediated transmission. Here we investigated of infection primary using wild-type Nef-mutated viruses. We show that facilitated activated cells. expressing enhanced activation proliferation resting However, when co-cultured with HIV-1-infected autologous DCs, there was no significant trend for infection- or Nef-dependent Our results suggest an important which likely contribute pathogenesis.
core.ac.uk
harvard.edu
plosone.org参考文章(71)
Nathalie J. Arhel, Frank Kirchhoff, Implications of Nef: Host Cell Interactions in Viral Persistence and Progression to AIDS Current Topics in Microbiology and Immunology. ,vol. 339, pp. 147- 175 ,(2009) , 10.1007/978-3-642-02175-6_8
G Englund, T S Theodore, E O Freed, A Engelman, M A Martin, Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1. Journal of Virology. ,vol. 69, pp. 3216- 3219 ,(1995) , 10.1128/JVI.69.5.3216-3219.1995
Kasia Hrecka, Caili Hao, Magda Gierszewska, Selene K. Swanson, Malgorzata Kesik-Brodacka, Smita Srivastava, Laurence Florens, Michael P. Washburn, Jacek Skowronski, Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein Nature. ,vol. 474, pp. 658- 661 ,(2011) , 10.1038/NATURE10195
Christopher M Coleman, Li Wu, HIV interactions with monocytes and dendritic cells: viral latency and reservoirs Retrovirology. ,vol. 6, pp. 51- 51 ,(2009) , 10.1186/1742-4690-6-51
Francesca Neri, Giorgia Giolo, Marina Potestà, Stefania Petrini, Margherita Doria, The HIV-1 Nef protein has a dual role in T cell receptor signaling in infected CD4+ T lymphocytes Virology. ,vol. 410, pp. 316- 326 ,(2011) , 10.1016/J.VIROL.2010.11.018
Li Wu, Arman A Bashirova, Thomas D Martin, Loreley Villamide, Erin Mehlhop, Andrei O Chertov, Derya Unutmaz, Melissa Pope, Mary Carrington, Vineet N KewalRamani, Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 1568- 1573 ,(2002) , 10.1073/PNAS.032654399
Derya Unutmaz, Vineet N. KewalRamani, Shana Marmon, Dan R. Littman, Cytokine Signals Are Sufficient for HIV-1 Infection of Resting Human T Lymphocytes Journal of Experimental Medicine. ,vol. 189, pp. 1735- 1746 ,(1999) , 10.1084/JEM.189.11.1735
Claudia Muratori, Lucas E. Cavallin, Kirsten Krätzel, Antonella Tinari, Angelo De Milito, Stefano Fais, Paola D'Aloja, Maurizio Federico, Vincenzo Vullo, Alla Fomina, Enrique A. Mesri, Fabiana Superti, Andreas S. Baur, Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells Cell Host & Microbe. ,vol. 6, pp. 218- 230 ,(2009) , 10.1016/J.CHOM.2009.06.009
Laura Burleigh, Pierre-Yves Lozach, Cécile Schiffer, Isabelle Staropoli, Valérie Pezo, Françoise Porrot, Bruno Canque, Jean-Louis Virelizier, Fernando Arenzana-Seisdedos, Ali Amara, Infection of Dendritic Cells (DCs), Not DC-SIGN-Mediated Internalization of Human Immunodeficiency Virus, Is Required for Long-Term Transfer of Virus to T Cells Journal of Virology. ,vol. 80, pp. 2949- 2957 ,(2006) , 10.1128/JVI.80.6.2949-2957.2006
Vincent Piguet, Olivier Schwartz, Sylvie Gall, Didier Trono, The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors. Immunological Reviews. ,vol. 168, pp. 51- 63 ,(1999) , 10.1111/J.1600-065X.1999.TB01282.X