Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells

摘要: Altered cytokine profiles and imbalanced frequencies of CD4(+) T helper cell subsets are thought to be linked with HIV-1/AIDS pathogenesis, but the causes need further clarified. Histamine, a biogenic amine many functions, shows enhancement in HIV-1 infected individuals, which considered link disease progression, is poorly understood. This study investigated histamine-assisted modulation dendritic (DC) functions. Histamine showed synergistic role induction interleukin-10; histamine inhibited HIV-1-induced IL-12 production from MDDCs (monocyte-derived DCs); notably, augmented MDDC functional polarization skewed naive differentiation toward regulatory cells (Tregs). The results indicate novel DC regulation, promoted Treg up-regulated immunosuppressive factors. These findings help bridge correlation between elevated increased frequency add our understanding immunosuppression.