The deviated balance between regulatory T cell and Th17 in autoimmunity.

摘要: Identifying the regulatory T cells (Tregs) and Th17 led to breaking dichotomy of Th1/Th2 axis in immune responses involved several autoimmune diseases. It is now well known that Tregs are main orchestra leaders pathogenesis symphony autoimmunity. While protective diseases, enhance progression through induction various pro-inflammatory reactions. seems autoimmunity may be associated with increase decrease Treg levels, so skewed balance between toward a phenomenon, which could observed during Although it suggested expansion transfer can new therapeutic target for however, recent data about phenotype conversion into obligate us more investigation on this approaching. Thus, identifying factors induce stable prevent their as targeting factor, modulate balance, might recommended promising method therapy. In review, we try clarify factors, affect targets treatment these