Eye movement disorders after frontal eye field lesions in humans

摘要: Eye movements were recorded electro-oculographically in three patients with a small ischemic lesion affecting the left frontal eye field (FEF) and 12 control subjects. Reflexive visually guided saccades (gap overlap tasks), antisaccades, predictive saccades, memory-guided smooth pursuit optokinetic nystagmus (OKN) studied patients. Staircase double step also one of For both leftward rightward latency task (but not gap task) that correct antisaccades was significantly increased, compared results controls. There significant decrease amplitude gain all programmed using retinotopic coordinates tasks, saccades), whereas corresponding preserved. Such an asymmetry between significant. In staircase paradigm as well for first saccade (with use cases), lower than saccades. Moreover, paradigm, second (programmed extraretinal signals), which The percentage errors antisaccade did differ from normal decreased. tested velocities, right higher OKN show, time humans, FEF plays important role (1) disengagement central fixation, (2) contralateral coordinates, (3) prediction (4) OKN, mainly ipsilaterally. contrast, appear to be crucial only type signals here.