Exploring Different Strategies for Efficient Delivery of Colorectal Cancer Therapy.

摘要: Colorectal cancer (CRC) is the third most common and fourth leading cause of death in world. Currently available chemotherapy CRC usually delivers drug to both normal as well cancerous tissues, thus numerous undesirable effects. Much emphasis being laid on development effective delivery systems for achieving selective active moiety at anticipated site action with minimized unwanted side Researchers have employed various techniques (dependent pH, time, pressure and/or bacteria) targeting drugs directly colonic region. On other hand, systemic strategies specific molecular targets (such FGFR, EGFR, CD44, EpCAM, CA IX, PPARγ COX-2) overexpressed by cells also been shown be effective. This review aims put forth an overview technologies that been, may developed, treatment CRC.