Association between Beckwith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patients.

摘要: Objective An association between assisted reproductive technique (ART) and specific imprinting mutations, such as Beckwith-Wiedemann syndrome (BWS), has recently been documented. Based on experiments in farm animals that demonstrated an alterations culture media during ART large offspring syndrome, we hypothesized the could be implicated a common factor among children with BWS conceived after ART. Design Retrospective case series. Setting Registry from Academic Medical Center. Patient(s) Nineteen born were identified within registry. Main outcome measure(s) Demographics of patients, type ART, media, IVF parameters. Result(s) Twelve 19 medical records endocrine centers successfully obtained. Ten 12 mothers had IVF, but no single, consistent was used this group. Half patients underwent intracytoplasmic sperm injection (ICSI; n=5), whereas other half routine IVF. One child through clomiphene citrate (CC) stimulation artificial insemination, another patient gonadotropin intrauterine insemination (IUI). The dosage quantity embryos transferred also varied significantly. only finding all women received some ovarian medication. Conclusion(s) Large epidemiologic studies are needed to further study