SIBLINGs and SPARC families: Their emerging roles in pancreatic cancer

摘要: Pancreatic cancer has a considerably poor prognosis with 5-year survival probability of less than 5% when all stages are combined. is characterized by its dense stroma, which involved in the critical interplay tumor cells throughout progression and furthermore, creates barrier restricting efficient penetration therapeutics. Alterations large number genes reflected limited signaling pathways, potential targets. Understanding more about molecular basis this devastating type regarding microenvironment, distinct subpopulations cells, epithelial-to-mesenchymal transition inflammation will lead to development various targeted therapies for controlling growth metastasis. In complex scenario pancreatic cancer, especially members “small integrin binding ligand N-linked glycoproteins” (SIBLINGs) “secreted protein acidic rich cysteine” (SPARC) families have emerged due their prominent roles properties including proliferation, differentiation, apoptosis, adhesion, migration, angiogenesis, wound repair regulation extracellular matrix remodeling. SIBLINGs consist five members, include osteopontin (OPN), bone sialoprotein, dentin 1, sialophosphoprotein phosphoglycoprotein. The SPARC family modular proteins comprised SPARC/osteonectin (ON) SPARC-like 1 (hevin); secreted calcium proteins; testicans follistatin-like protein. review, we focus on OPN ON, elaborating special growing importance diagnosis prognosis.