TRPV1: A Potential Therapeutic Target in Type 2 Diabetes and Comorbidities?
作者： Dorte X Gram , Jens J Holst , Arpad Szallasi , None
DOI: 10.1016/J.MOLMED.2017.09.005
关键词:
摘要: With an estimated 422 million affected patients worldwide in 2016, type 2 diabetes (T2D) has reached pandemic proportions and represents a major unmet medical need. T2D is polygenic disease with chronic, low-grade inflammatory component. Second-generation transient receptor potential vanilloid-1 (TRPV1) antagonists are potent anti-inflammatory agents proven clinical safety. In rodent models of T2D, TRPV1 blockade was shown to halt progression improve glucose metabolism. Thus, we propose that merit further study as novel therapeutic approaches potentially treat its comorbidities.
sci-hub.se 参考文章(87)
Arpad Szallasi, Peter M. Blumberg, Complex Regulation of TRPV1 by Vanilloids CRC Press/Taylor & Francis. ,(2007)
E L Lamos, S A Stein, S N Davis, Sulfonylureas and meglitinides: historical and contemporary issues. Panminerva Medica. ,vol. 55, pp. 239- 251 ,(2013)
Edwin J.P. van Asseldonk, Pleun C.M. van Poppel, Dov B. Ballak, Rinke Stienstra, Mihai G. Netea, Cees J. Tack, One week treatment with the IL-1 receptor antagonist anakinra leads to a sustained improvement in insulin sensitivity in insulin resistant patients with type 1 diabetes mellitus. Clinical Immunology. ,vol. 160, pp. 155- 162 ,(2015) , 10.1016/J.CLIM.2015.06.003
Nemanja Jovicic, Ilija Jeftic, Ivan Jovanovic, Gordana Radosavljevic, Nebojsa Arsenijevic, Miodrag L. Lukic, Nada Pejnovic, Differential Immunometabolic Phenotype in Th1 and Th2 Dominant Mouse Strains in Response to High-Fat Feeding. PLOS ONE. ,vol. 10, ,(2015) , 10.1371/JOURNAL.PONE.0134089
Louis S. Premkumar, Gerard P. Ahern, Induction of vanilloid receptor channel activity by protein kinase C Nature. ,vol. 408, pp. 985- 990 ,(2000) , 10.1038/35050121
Michael J. Caterina, Mark A. Schumacher, Makoto Tominaga, Tobias A. Rosen, Jon D. Levine, David Julius, The capsaicin receptor: a heat-activated ion channel in the pain pathway Nature. ,vol. 389, pp. 816- 824 ,(1997) , 10.1038/39807
Dorte Xenia Gram, Anker Jon Hansen, Inhibition of the activity of the capsaicin receptor in the treatment of type 1 diabetes, type 2 diabetes, impaired glucose tolerance or insulin resistance ,(2010)
JI Nagy, LL Iversen, M Goedert, D Chapman, SP Hunt, Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat The Journal of Neuroscience. ,vol. 3, pp. 399- 406 ,(1983) , 10.1523/JNEUROSCI.03-02-00399.1983
David L. Morris, Minireview: Emerging Concepts in Islet Macrophage Biology in Type 2 Diabetes Molecular Endocrinology. ,vol. 29, pp. 946- 962 ,(2015) , 10.1210/ME.2014-1393
Arianne L. Motter, Gerard P. Ahern, TRPV1-null mice are protected from diet-induced obesity FEBS Letters. ,vol. 582, pp. 2257- 2262 ,(2008) , 10.1016/J.FEBSLET.2008.05.021