Leucine and Resveratrol: Experimental Model of Sirtuin Pathway Activation
作者： Antje Bruckbauer , Michael B. Zemel
DOI: 10.1007/978-1-4939-1923-9_8
关键词:
摘要: The beneficial effects of leucine and resveratrol on health are largely dependent activation the sirtuin pathway. silent information regulator (Sir) proteins, also called sirtuins, a conserved family histone protein deacetylases that use NAD+ as co-substrate [1]. This NAD+-dependence links sirtuins to metabolic activity cells, thus regulating numerous physiologic pathways. Accordingly, they have been implicated in prevention disorders such insulin resistance, diabetes, cardiovascular disease, cancer well aging [2].
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Michael Zemel, Brooke Baggett, Antje Bruckbauer, Synergistic Effects of Leucine and its Metabolites with Polyphenols on Irisin in Myotubes and Diet-induced Obese Mice The FASEB Journal. ,vol. 27, ,(2013)
S. E. McCormack, O. Shaham, M. A. McCarthy, A. A. Deik, T. J. Wang, R. E. Gerszten, C. B. Clish, V. K. Mootha, S. K. Grinspoon, A. Fleischman, Circulating branched‐chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents Pediatric Obesity. ,vol. 8, pp. 52- 61 ,(2013) , 10.1111/J.2047-6310.2012.00087.X
Xiaocun Sun, Michael B Zemel, Leucine and Calcium Regulate Fat Metabolism and Energy Partitioning in Murine Adipocytes and Muscle Cells Lipids. ,vol. 42, pp. 297- 305 ,(2007) , 10.1007/S11745-007-3029-5
Vera B Schrauwen-Hinderling, Michael Roden, M Eline Kooi, Matthijs KC Hesselink, Patrick Schrauwen, Muscular mitochondrial dysfunction and type 2 diabetes mellitus. Current Opinion in Clinical Nutrition and Metabolic Care. ,vol. 10, pp. 698- 703 ,(2007) , 10.1097/MCO.0B013E3282F0ECA9
Edward J Calabrese, Mark P Mattson, Vittorio Calabrese, Resveratrol commonly displays hormesis: occurrence and biomedical significance. Human & Experimental Toxicology. ,vol. 29, pp. 980- 1015 ,(2010) , 10.1177/0960327110383625
Yi Liu, Qiang Wan, Qingbo Guan, Ling Gao, Jiajun Zhao, High-fat diet feeding impairs both the expression and activity of AMPKa in rats' skeletal muscle. Biochemical and Biophysical Research Communications. ,vol. 339, pp. 701- 707 ,(2006) , 10.1016/J.BBRC.2005.11.068
Thomas P Wycherley, Lisa J Moran, Peter M Clifton, Manny Noakes, Grant D Brinkworth, Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trials The American Journal of Clinical Nutrition. ,vol. 96, pp. 1281- 1298 ,(2012) , 10.3945/AJCN.112.044321
Marie-Soleil Gauthier, Elena L O’Brien, Sherman Bigornia, Melanie Mott, Jose M Cacicedo, X. Julia Xu, Noyan Gokce, Caroline Apovian, Neil Ruderman, Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans Biochemical and Biophysical Research Communications. ,vol. 404, pp. 382- 387 ,(2011) , 10.1016/J.BBRC.2010.11.127
Julia Brenmoehl, Andreas Hoeflich, Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3. Mitochondrion. ,vol. 13, pp. 755- 761 ,(2013) , 10.1016/J.MITO.2013.04.002
Jonathan P. Little, Adeel Safdar, David Bishop, Mark A. Tarnopolsky, Martin J. Gibala, An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 300, ,(2011) , 10.1152/AJPREGU.00538.2010