Effects of ozone nano-bubble water on periodontopathic bacteria and oral cells - in vitro studies

摘要: The aims of the present study were to evaluate bactericidal activity a new antiseptic agent, ozone nano-bubble water (NBW3), against periodontopathogenic bacteria and assess cytotoxicity NBW3 human oral cells. activities representative bacteria, Porphyromonas gingivalis (P. gingivalis) Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) evaluated using in vitro time-kill assays. was three-dimensional buccal gingival tissue models. numbers colony forming units (CFUs)/mL P. A. exposed dropped below lower limit detection (<10 CFUs mL−1) after only 0.5 min exposure. There minor decreases viability cells 24 h exposure NBW3. These results suggest that possesses potent is not cytotoxic tissues. use as an adjunct periodontal therapy would be promising.