Noise enhanced hormonal signal transduction through intracellular calcium oscillations.
作者： Leonhard Läer , Mirko Kloppstech , Christof Schöfl , Terrence J. Sejnowski , Georg Brabant
DOI: 10.1016/S0301-4622(01)00167-3
关键词:
摘要: In a wide range of non-linear dynamical systems, noise may enhance the detection weak deterministic input signals. Here, we demonstrate this phenomenon for transmembrane signaling in hormonal model system intracellular Ca(2+) oscillations. Adding Gaussian to subthreshold extracellular pulsatile stimulus increased sensitivity dose-response relation oscillations compared same signal added as constant mean level. These findings have important physiological consequences operation and other transduction systems close threshold
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