Substance Use Disorders and Neuro-AIDS in the HAART Era

摘要: This chapter reviews the studies which provide evidence for a synergistic effect of drugs abuse and human immunodeficiency virus (HIV) infection on brain function. Understanding interactive mechanisms this neurodegeneration is critical to our ability optimize therapy drug-abusing HIV-infected populations. The discusses proposed underlying combined neurotoxicity, current state knowledge about role highly active antiretroviral (HAART) in interaction, implications future research therapeutic development. It that each interacts with HIV through influences dopaminergic system by other as well. A recent study showed morphine inhibits CD8-positive T-cell-mediated noncytotoxic anti-HIV activity latently infected immune cells, largely interfering gamma interferon signaling pathway. Naltrexone blocked morphine-induced inhibition. suggests impairs function system. In injection drug users, HAART utilization decreases mortality compared nonutilization, though all or without utilization, have better survival era than pre-HAART era. By stopping discussed chapter, it would seem reasonable abstinence halt potentially reverse progression HIV-associated dementia individuals. Further work needed develop new strategies benefit population.