Gastric Helicobacter Infection Inhibits Development of Oral Tolerance to Food Antigens in Mice

摘要: The increase in the transcellular passage of intact antigens across digestive epithelium infected with Helicobacter pylori may interfere regulation mucosal immune responses. aim this work was to study capacity infection inhibit development oral tolerance or promote allergic sensitization and a gastro-protective agent, rebamipide, these processes mice. Oral ovalbumin (OVA) studied 48 C3H/He 4-week-old mice divided into four groups: (i) OVA-sensitized mice; (ii) OVA-“tolerized” (that is, that were rendered immunologically tolerant); (iii) H. felis-infected, OVA-tolerized (iv) OVA-tolerized, rebamipide-treated hen egg lysozyme (HEL) controls; HEL-sensitized HEL-sensitized, Specific anti-OVA anti-HEL immunoglobulin E (IgE) IgG1/IgG2a serum titers measured by enzyme-linked immunosorbent assay. Additionally, rebamipide antigen presentation T-cell activation vitro, as well absorption epithelial monolayer, tested. felis led inhibition OVA, but prevented inhibitive effect felis. did not enhance HEL, inhibited sensitization. Moreover, dose-dependent manner vitro shown be able cross at concentration capable inducing inhibitory effect. We conclude can OVA is rebamipide.