作者: B. Charbonnel
DOI: 10.1016/S0924-9338(05)80186-5
关键词:
摘要: Diabetes mellitus is a complex metabolic disorder, caused by defects in insulin action and/or production and defined as afasting hyperglycaemia of >126 mg/dl, with normoglycaemia being ≥70 ≤ 110 mg/dl. There are two main types diabetes. Type 1 diabetes (around 10% cases) an autoimmune disease, usually early onset, which pancreatic islet beta cells that secrete destroyed. 2 85% characterised principally resistance impaired secretion. Heredity obesity major risk factors for associated potentially life-threatening microvascular macrovascular complications elevated serum glucose levels. Treatment aims at restoring glycaemic control. In diabetes, this can be achieved injecting insulin. Oral hypoglycaemic medications stimulate secretion modify metabolism used first-line treatment mellitus. However, necessary later phases the disease. Lifestyle changes, such diet exercise, also important. Glycaemic control measured fasting blood levels glycosylated haemoglobin The latter measure gives indication over period three months, reduction most appropriate goal management