Improvement in the intestinal processes of hydroelectrolytic absorption and secretion in abdominal pathologies of surgical interest treated with SMS 201-995: experimental protocol.

摘要: The hypothesis that octreotide can improve the intestinal absorption and secretion processes in a mixed group of pathologies, this effect varies according to pathology question, was tested. One hunded twenty Wistar rats were randomly assigned six groups consisting three occlusions including (1) complete, (2) partial, (3) complete with strangulation, mesenteric vascular (4) partial permanent, (5) total (6) temporary. Each contained ten control treated rats. animals received (100 μg/kg body weight) while controls given same quantity saline solution every 8 h. After observation period, contents small intestine extracted its volume measured before after centrifugation; concentration content Na, K, Cl, bicarbonate then analyzed. Samples all intestines at specific distances from lesion zone stained, evaluated score quantify lesions. electrolytes (before centrifugation) lower animals, but varied pathology. There nonadditive influence between type treatment for four volume. effects drug make it directly or indirectly possible decrease lesions absorption-secretion processes. Octreotide acts on pathologies analyzed except permanent ischemia. Its action also involved.