Somatostatin and octreotide in gastroenterology

作者: A. K. BURROUGHS , P. A. McCORMICK

DOI: 10.1111/J.1365-2036.1991.TB00036.X

关键词:

摘要: Somatostatin and octreotide have a definitive role in the management of symptomatic gut neuroendocrine tumours, particularly VIPomas carcinoid. They probably also variceal bleeding, but this needs further confirmatory randomized trials. At present there is potential short bowel syndrome, dumping syndrome gastrointestinal fistulae, clinical studies are needed. Possibly AIDS-related diarrhoea 'idiopathic' secretory diarrhoea, more evidence required. no acute pancreatitis peptic ulcer bleeding. Irritable remains unexplored unlikely to benefit.

参考文章(47)
E. J. Mozell, B. Howe, E. A. Woltering, J. Fletcher, D. Hill, W. S. Fletcher, D. Rhea, B. E. Phillipson, T. M. O'Dorisio, Adult onset nesidioblastosis : Response of glucose, insulin, and secondary peptides to therapy with Sandostatin The American Journal of Gastroenterology. ,vol. 85, pp. 181- 188 ,(1990)
Annemarie Koelz, Marius Kraenzlin, Klaus Gyr, Verena Meier, Stephen R. Bloom, Philipp Heitz, Hans Stalder, Escape of the Response to a Long-Acting Somatostatin Analogue (SMS 201-995) in Patients With VIPoma Gastroenterology. ,vol. 92, pp. 527- 531 ,(1987) , 10.1016/0016-5085(87)90153-3
Andrew K. Burroughs, P.Aiden McCormick, Michael D. Hughes, Dirk Sprengers, Francois D'heygere, Neil McIntyre, Randomized, double-blind, placebo-controlled trial of somatostatin for variceal bleeding Gastroenterology. ,vol. 99, pp. 1388- 1395 ,(1990) , 10.1016/0016-5085(90)91166-4
Robert S. Fisher, Elizabeth Rock, Gary Levin, Leon Malmud, Effects of Somatostatin on Gallbladder Emptying Gastroenterology. ,vol. 92, pp. 885- 890 ,(1987) , 10.1016/0016-5085(87)90961-9
Olav Øktedalen, Knut Nygaard, Magne Osnes, Somatostatin in the treatment of pancreatic ascites Gastroenterology. ,vol. 99, pp. 1520- 1521 ,(1990) , 10.1016/0016-5085(90)91187-B
A.Majid Molla, Klaus Gyr, P.K. Bardhan, Ayesha Molla, Effect of intravenous somatostatin on stool output in diarrhea due to Vibrio cholerae. Gastroenterology. ,vol. 87, pp. 845- 847 ,(1984) , 10.1016/0016-5085(84)90078-7
Michael R. Ruff, Brian M. Martin, Edward I. Ginns, William L. Farrar, Candace B. Pert, CD4 receptor binding peptides that block HIV infectivity cause human monocyte chemotaxis FEBS Letters. ,vol. 211, pp. 17- 22 ,(1987) , 10.1016/0014-5793(87)81265-6
Marie F. Sharkey, Mark L. Kadden, Bruce E. Stabile, Severe posthemicolectomy diarrhea: evaluation and treatment with SMS 201-995. Gastroenterology. ,vol. 99, pp. 1144- 1148 ,(1990) , 10.1016/0016-5085(90)90637-G
Robert H. Resnick, Somatostatin for variceal bleeders Gastroenterology. ,vol. 99, pp. 1524- 1526 ,(1990) , 10.1016/0016-5085(90)91189-D
Raimondo Cerini, Samuel S. Lee, Antoine Hadengue, Abraham Koshy, Catherine Girod, Didier Lebrec, Circulatory effects of somatostatin analogue in two conscious rat models of portal hypertension. Gastroenterology. ,vol. 94, pp. 703- 708 ,(1988) , 10.1016/0016-5085(88)90242-9