Translational regulation of mitochondrial biogenesis
作者： Yi Zhang , Hong Xu
DOI: 10.1042/BST20160071C
关键词:
摘要: Mitochondria are generated by the expression of genes on both nuclear and mitochondrial genome. Mitochondrial biogenesis is highly plastic in response to cellular energy demand, developmental signals environmental stimuli. Mechanistic target rapamycin (mTOR) pathway regulates co-ordinate homeostasis with cell growth. The local translation proteins outer membrane facilitates their efficient import thereby allows prodigious during rapid growth proliferation. We postulate that may also allow cells promote selectively based fitness individual organelle. MDI-Larp complex promotes healthy mitochondria essential for selective transmission mitochondria. On other hand, PTEN-induced putative kinase 1 (PINK1)-Pakin activates protein synthesis damaged maintain organelle activity. summarize some recent progress miRNAs' regulation biogenesis.
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Rod E. Kellems, Ronald A. Butow, Cytoplasmic-type 80 S Ribosomes Associated with Yeast Mitochondria I. EVIDENCE FOR RIBOSOME BINDING SITES ON YEAST MITOCHONDRIA Journal of Biological Chemistry. ,vol. 247, pp. 8043- 8050 ,(1972) , 10.1016/S0021-9258(20)81806-7
Alicia M. Pickrell, Chiu-Hui Huang, Scott R. Kennedy, Alban Ordureau, Dionisia P. Sideris, Jake G. Hoekstra, J. Wade Harper, Richard J. Youle, Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress Neuron. ,vol. 87, pp. 371- 381 ,(2015) , 10.1016/J.NEURON.2015.06.034
Rod E. Kellems, Venita F. Allison, Ronald A. Butow, Cytoplasmic Type 80 S Ribosomes Associated with Yeast Mitochondria II. EVIDENCE FOR THE ASSOCIATION OF CYTOPLASMIC RIBOSOMES WITH THE OUTER MITOCHONDRIAL MEMBRANE IN SITU Journal of Biological Chemistry. ,vol. 249, pp. 3297- 3303 ,(1974) , 10.1016/S0021-9258(19)42672-0
J. Tcherkezian, M. Cargnello, Y. Romeo, E. L. Huttlin, G. Lavoie, S. P. Gygi, P. P. Roux, Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5′TOP mRNA translation Genes & Development. ,vol. 28, pp. 357- 371 ,(2014) , 10.1101/GAD.231407.113
Teresa C Leone, John J Lehman, Brian N Finck, Paul J Schaeffer, Adam R Wende, Sihem Boudina, Michael Courtois, David F Wozniak, Nandakumar Sambandam, Carlos Bernal-Mizrachi, Zhouji Chen, John O. Holloszy, Denis M Medeiros, Robert E Schmidt, Jeffrey E Saffitz, E. Dale Abel, Clay F Semenkovich, Daniel P Kelly, PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLOS Biology. ,vol. 3, pp. 672- 687 ,(2005) , 10.1371/JOURNAL.PBIO.0030101
Peter Rehling, Kirstin Model, Katrin Brandner, Peter Kovermann, Albert Sickmann, Helmut E Meyer, Werner Kühlbrandt, Richard Wagner, Kaye N Truscott, Nikolaus Pfanner, Protein insertion into the mitochondrial inner membrane by a twin-pore translocase Science. ,vol. 299, pp. 1747- 1751 ,(2003) , 10.1126/SCIENCE.1080945
Daniel F. Bogenhagen, Dwight W. Martin, Antonius Koller, Initial Steps in RNA Processing and Ribosome Assembly Occur at Mitochondrial DNA Nucleoids Cell Metabolism. ,vol. 19, pp. 618- 629 ,(2014) , 10.1016/J.CMET.2014.03.013
Vera Kozjak, Nils Wiedemann, Dusanka Milenkovic, Christiane Lohaus, Helmut E. Meyer, Bernard Guiard, Chris Meisinger, Nikolaus Pfanner, An Essential Role of Sam50 in the Protein Sorting and Assembly Machinery of the Mitochondrial Outer Membrane Journal of Biological Chemistry. ,vol. 278, pp. 48520- 48523 ,(2003) , 10.1074/JBC.C300442200
Weiwei Fan, Ronald Evans, PPARs and ERRs: molecular mediators of mitochondrial metabolism. Current Opinion in Cell Biology. ,vol. 33, pp. 49- 54 ,(2015) , 10.1016/J.CEB.2014.11.002
Justin C. St John, Transmission, inheritance and replication of mitochondrial DNA in mammals: implications for reproductive processes and infertility Cell and Tissue Research. ,vol. 349, pp. 795- 808 ,(2012) , 10.1007/S00441-012-1444-2