Relative bioavailability of gastrodin and parishin from extract and powder of Gastrodiae rhizoma in rat
作者： Yang Zhao , Xiao-Jian Gong , Xin Zhou , Zhi-Jiao Kang
DOI: 10.1016/J.JPBA.2014.08.017
关键词:
摘要: A rapid, sensitive and reliable UHPLC-ESI-MS/MS method was developed for simultaneous determination of gastrodin parishin in rat plasma. The LLOQ the two analytes were 1.00×10(-1) 8.30×10(-5)μg/mL, respectively. intra-day inter-day precision all less than 10% relative standard deviation (RSD), whilst accuracy within ±15% error (RE). proposed successfully applied pharmacokinetics study on rats after oral administration Gastrodiae rhizoma (GR) extract powder at low, medium high dosages. Blood samples collected from suborbital vein predetermined time points precipitated using methanol. Chromatographic separations carried out a Kinetex XB-C18 column (2.1mm×150mm, 1.7μm) with gradient mobile phase acetonitrile-water 0.1% formic acid as modifier. pharmacokinetic parameters obtained bioavailability formulations calculated. results indicated that higher when low dosage GR used, whereas, values dosages used.
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sci-hub.se 参考文章(19)
C. L. Liu, M. C. Liu, P. L. Zhu, Determination of gastrodin,p-hydroxybenzyl alcohol, vanillyl alcohol,p-hydroxylbenzaldehyde and vanillin in tall gastrodia tuber by high-performance liquid chromatography Chromatographia. ,vol. 55, pp. 317- 320 ,(2002) , 10.1007/BF02491665
Ji Wook Jung, Byung Hoon Yoon, Hye Rim Oh, Jae-Hyeong Ahn, Sun Yeou Kim, Sang-Yong Park, Jong Hoon Ryu, Anxiolytic-like effects of Gastrodia elata and its phenolic constituents in mice. Biological & Pharmaceutical Bulletin. ,vol. 29, pp. 261- 265 ,(2006) , 10.1248/BPB.29.261
Ching-Liang Hsieh, Chin-Hsien Chang, Su-Yin Chiang, Tsai-Chung Li, Nou-Ying Tang, Chu-Zong Pon, Ching-Tou Hsieh, Jaung-Geng Lin, None, Anticonvulsive and free radical scavenging activities of vanillyl alcohol in ferric chloride-induced epileptic seizures in Sprague-Dawley rats. Life Sciences. ,vol. 67, pp. 1185- 1195 ,(2000) , 10.1016/S0024-3205(00)00706-2
Jer-Huei Lin, Yi-Chu Liu, Jiing-Ping Hau, Kuo-Ching Wen, Parishins B and C from rhizomes of Gastrodia elata Phytochemistry. ,vol. 42, pp. 549- 551 ,(1996) , 10.1016/0031-9422(95)00955-8
Li Jiang, Jundong Dai, Zhenlin Huang, Qinghua Du, Jiahao Lin, Yurong Wang, Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics Journal of Chromatography B. ,vol. 915, pp. 8- 12 ,(2013) , 10.1016/J.JCHROMB.2012.12.011
Ching-Liang Hsieh, Chi-Long Chen, Nou-Ying Tang, Chin-Min Chuang, Ching-Tou Hsieh, Su-Yin Chiang, Jaung-Geng Lin, Sheng-Feng Hsu, Gastrodia elata BL Mediates the Suppression of nNOS and Microglia Activation to Protect Against Neuronal Damage in Kainic Acid-Treated Rats The American Journal of Chinese Medicine. ,vol. 33, pp. 599- 611 ,(2005) , 10.1142/S0192415X0500320X
W. Zhang, Y.X. Sheng, J.L. Zhang, Determination and pharmacokinetics of gastrodin and p-hydroxybenzylalcohol after oral administration of Gastrodia elata Bl. extract in rats by high-performance liquid chromatography-electrospray ionization mass spectrometric method. Phytomedicine. ,vol. 15, pp. 844- 850 ,(2008) , 10.1016/J.PHYMED.2008.02.012
Junko Hayashi, Toshikazu Sekine, Shigeyoshi Deguchi, Qing Lin, Syunji Horie, Shizuko Tsuchiya, Shingo Yano, Kazuo Watanabe, Fumio Ikegami, Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds on isolated smooth muscle preparation. Phytochemistry. ,vol. 59, pp. 513- 519 ,(2002) , 10.1016/S0031-9422(02)00008-0
Hyeon-Ju Kim, Kwang-Deog Moon, Sang-Young Oh, Sang-Pyo Kim, Seong-Ryong Lee, Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus Neuroscience Letters. ,vol. 314, pp. 65- 68 ,(2001) , 10.1016/S0304-3940(01)02296-0
Ching-Liang Hsieh, Su-Yin Chiang, Ken-Sheng Cheng, Yu-Hsien Lin, Nou-Ying Tang, Chia-Jung Lee, Chu-Zong Pon, Ching-Tou Hsieh, Anticonvulsive and free radical scavenging activities of Gastrodia elata Bl. in kainic acid-treated rats. The American Journal of Chinese Medicine. ,vol. 29, pp. 331- 341 ,(2001) , 10.1142/S0192415X01000356