Preparation, characterization, in vivo and biochemical evaluation of brain targeted Piperine solid lipid nanoparticles in an experimentally induced Alzheimer’s disease model

摘要: Background: Alzheimer is a fast growing disease with imprecise chemical treatments. Increased oxidative stress, decrease in acetylcholine concentration, and appearance of amyloidal proteins are reported pathology Alzheimer. Chemical drugs effective but on the cost detrimental side effects.Purpose: Present research based Preparation, characterization, behavioral biochemical evaluation brain targeted Piperine solid lipid nanoparticles an experimentally induced Alzheimer’s model at low dose 2 mg/kg.Methods: were prepared by Emulsification-Solvent Diffusion technique polysorbate-80 coating to impart Brain specific targeting. Experimental Ibotenic acid Alzheimer’s, Force swimming test, superoxide dismutase, acetylcholenesterase enzymatic assays also Histopathology cortex was conducted evaluate therapeutic effects Disease.Results: nanoformulation (2 mg/kg equivale...