Intrahepatic Cholestasis of Pregnancy (ICP): A Patho-Physiological Review

摘要: Intrahepatic cholestasis is a pregnancy-specific liver disorder characterized by maternal pruritus in the third trimester, raised serum bile acids and increased rates of adverse fetal outcomes, generally faced genetically predisposed women up to moderate severe stage that cause skin itching make life debilitating but not fatal during time pregnancy often after second trimester rarely before that,alleviation this difficulty achieved using pharamcological measures. The etiology ICP its molecular mechanism complex fully understood, it likely result from cholestatic effects reproductive hormones their metabolites. Equally unclear are mechanisms which complications occur. This article reviews probable future therapeutic target for alleviation outcome.