Lack of insulin impairs Mg2+ homeostasis and transport in cardiac cells of streptozotocin‐injected diabetic rats

摘要: Serum and tissue Mg(2+) content are markedly decreased in diabetic patients animals. At the level, loss progresses over time affects predominantly heart, liver skeletal muscles. In present study, alterations homeostasis transport cardiac ventricular myocytes were evaluated. Cardiac isolated from animals displayed a decrease total that affected all cellular compartments. This was associated with marked reduction protein ATP content. Diabetic unable to mobilize following beta-adrenergic receptor stimulation or addition of cell permeant cyclic-AMP. Sarcolemma vesicles purified animals, however, transported normally as compared non-diabetic Treatment exogenous insulin for 2 weeks restored levels well comparable those observed These results suggest cells extrusion via beta-adrenergic/cAMP signaling by concomitant As regulates numerous enzymes functions, including synthesis, these provide new rationale interpret some aspects dysfunctions under conditions.