Process for the preparation of high purity methotrexate and derivatives thereof

摘要: An improved process for the preparation and purification of N-{p-([2,4-diamino-6-pteridinyl)-methyl]methylamino)benzoyl} glutamic acid, also known as methotrexate, using alkali metal, calcium zinc salts N-methyl-p-aminobenzoylglutamate, tetraaminopyrimidine sulfate, 1,1,3-tribromoacetone metal methotrexate.