Different expression of glucose transporters in the progression of intrahepatic cholangiocarcinoma

摘要: Glucose transporter (GLUT)-1 is expressed in malignant tumors and correlated with poor outcome several cancers. Biliary intraepithelial neoplasia (BilIN) considered to be a precursor or noninvasive lesion of invasive cholangiocarcinoma. We examined GLUT-1 GLUT-2 expression 149 intrahepatic cholangiocarcinomas 39 BilINs immunohistochemically evaluated their correlation clinicopathological findings patient Furthermore, we the role on migration invasion cholangiocarcinoma cells using siRNA. In cholangiocarcinoma, was frequently observed near necrotic areas, whereas tended adenocarcinoma large bile ducts. Compared GLUT-1-negative group, GLUT-1-positive group showed significantly larger tumor size (P = .0031), differentiation < .0001), frequent lymphatic .0031) lymph node metastasis high HIF-1α .0297). good .0015), perihilar location perineural .0049), .0248). The patients disease related survival .0001). numbers migrating invading were decreased siRNA transfectants cells. Although, all grades BilINs, only high-grade BilINs. Our results suggest that correlates aggressive behavior prognosis, might therapeutic target may associated cholangiocarcinogenesis duct helpful marker for detecting BilIN lesions atypical