Clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues.
作者： Xiaoping Ma , Yuzuo Hui , Li Lin , Yu Wu , Xian Zhang
关键词:
摘要: OBJECTIVE: To analyze the clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues. METHODS: One hundred eight tissue samples from patients with enrolled our hospital August 2011 to July 2014 were selected, including 60 normal (normal group), neoplastic (neoplastic group) (cancer group). All subjected immunohistochemical assay detect VEGF. The data also investigated for correlation analysis. RESULTS: positive rates COX-2 group, group groups 3.3%, 21.7% 55.0% respectively. 25.0% 70.0% 1.7%, 23.3% 63.3% With increasing stage such cancer, decreasing degree differentiation lymphatic metastasis, expression proteins raised significantly (P<0.05). Spearman's analysis showed that (r=0.207, P<0.05), (r=0.243, as well (r=0.758, P<0.05) positively correlated. CONCLUSION: highly prominent especially low differentiation, late metastasis. They functioned synergistically onset progression this cancer.
pjms.com.pk
sci-hub.se 参考文章(22)
Y F Zhou, Y Xiong, Y Y Xiong, Expression and significance of beta-catenin, Glut-1 and PTEN in proliferative endometrium, endometrial intraepithelial neoplasia and endometrioid adenocarcinoma. European Journal of Gynaecological Oncology. ,vol. 31, pp. 160- 164 ,(2010)
T. Dragovich, D. Laheru, F. Dayyani, V. Bolejack, L. Smith, J. Seng, H. Burris, P. Rosen, M. Hidalgo, P. Ritch, A. F. Baker, N. Raghunand, J. Crowley, D. D. Von Hoff, Phase II trial of vatalanib in patients with advanced or metastatic pancreatic adenocarcinoma after first-line gemcitabine therapy (PCRT O4-001) Cancer Chemotherapy and Pharmacology. ,vol. 74, pp. 379- 387 ,(2014) , 10.1007/S00280-014-2499-4
Irune Ruiz, Maialen Martín-Arruti, Elixabet Lopez-Lopez, Africa Garcia-Orad, Lack of association between deficient mismatch repair expression and outcome in endometrial carcinomas of the endometrioid type. Gynecologic Oncology. ,vol. 134, pp. 20- 23 ,(2014) , 10.1016/J.YGYNO.2014.04.053
Chang Ohk Sung, Insuk Sohn, The expression pattern of 19 genes predicts the histology of endometrial carcinoma Scientific Reports. ,vol. 4, pp. 5174- 5174 ,(2015) , 10.1038/SREP05174
Yuichiro Kubo, Shinichi Aishima, Yuki Tanaka, Koji Shindo, Yusuke Mizuuchi, Koichiro Abe, Ken Shirabe, Yoshihiko Maehara, Hiroshi Honda, Yoshinao Oda, Different expression of glucose transporters in the progression of intrahepatic cholangiocarcinoma Human Pathology. ,vol. 45, pp. 1610- 1617 ,(2014) , 10.1016/J.HUMPATH.2014.03.008
Gyftopoulos Kostis, Lilis Ioannis, Kourea Helen, Papadaki Helen, None, The expression of vascular endothelial growth factor-C correlates with lymphatic microvessel density and lymph node metastasis in prostate carcinoma: An immunohistochemical study. Urology Annals. ,vol. 6, pp. 224- 230 ,(2014) , 10.4103/0974-7796.134275
Sandeepa M. Eswarappa, Alka A. Potdar, William J. Koch, Yi Fan, Kommireddy Vasu, Daniel Lindner, Belinda Willard, Linda M. Graham, Paul E. DiCorleto, Paul L. Fox, Programmed Translational Readthrough Generates Antiangiogenic VEGF-Ax Cell. ,vol. 157, pp. 1605- 1618 ,(2014) , 10.1016/J.CELL.2014.04.033
Melissa Much, Natalia Buza, Pei Hui, Tissue identity testing of cancer by short tandem repeat polymorphism: pitfalls of interpretation in the presence of microsatellite instability. Human Pathology. ,vol. 45, pp. 549- 555 ,(2014) , 10.1016/J.HUMPATH.2013.10.022
Agnieszka Jęda, Andrzej Witek, Grażyna Janikowska, Grzegorz Cwynar, Tomasz Janikowski, Małgorzata Ciałoń, Joanna Orchel, Urszula Mazurek, [Expression profile of genes associated with the histaminergic system estimated by oligonucleotide microarray analysis HG-U133A in women with endometrial adenocarcinoma]. Ginekologia Polska. ,vol. 85, pp. 172- ,(2014) , 10.17772/GP/1709
Ellen Stelloo, Remi A. Nout, Lisanne C.L.M. Naves, Natalja T. ter Haar, Carien L. Creutzberg, Vincent T.H.B.M. Smit, Tjalling Bosse, High concordance of molecular tumor alterations between pre-operative curettage and hysterectomy specimens in patients with endometrial carcinoma. Gynecologic Oncology. ,vol. 133, pp. 197- 204 ,(2014) , 10.1016/J.YGYNO.2014.02.012