Inducible Models of Bone Loss

摘要: Bone is an essential organ that not only confers structural stability to the organism, but also serves as a reservoir for hematopoietic elements and thought affect systemic homeostasis through release of endocrine factors well calcium. The loss bone mass due uncoupling formation resorption leads increased fragility can result in devastating fractures. Further understanding effects environmental stimuli on development disease humans needed, be studied using animal models. In this chapter, we present established novel methods induction mice, including manipulation diet environment, drug administration, irradiation, hormone deficiency. All these models are directly related human cases, thus used investigate causes resulting from interventions.