Post-translational histone modifications and their interaction with sex influence normal brain development and elaboration of neuropsychiatric disorders.
作者： G. Singh , V. Singh , J.S. Schneider
DOI: 10.1016/J.BBADIS.2018.10.016
关键词:
摘要: Sex differences in the risk for and expression of various brain disorders have been known some time. Yet, molecular underpinnings these sex as well how modifies normal development are still poorly understood. It has recently become that epigenetic mechanisms play an essential role establishing maintaining neurodevelopment disease susceptibility. Epigenetic such post-translational modifications histones (histone PTMs) integrate hormonal external environmental influences to affect genomic output, this appears occur a sex-dependent manner. The present review aims highlight current understanding histone PTMs sexual differentiation under conditions sex-specific modulation may be involved psychiatric including autism spectrum disorder (ASD), schizophrenia, major depressive (MDD). chromosome genes modifiers their importance sexually differentiating will discussed. Further, contribution PTM marks placenta programming dimorphic developmental course susceptibility diseases/disorders reviewed. Prenatal long-lasting effect on adult behavior but due interaction its with fluctuating hormone levels over lifespan, process remains dynamic. Although few studies indicate association between PTM-related ASD, MDD, more research is needed fully appreciate interactive effects manifestation disorders. Understanding interactions advance our potentially guide future treatments tailored specifically each sex.
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