Adrenergic Receptor Sensitivity in Depression
作者： Dennis S. Charney
DOI: 10.1001/ARCHPSYC.1982.04290030030005
关键词:
摘要: • Several recent investigations have raised the possibility that sensitivity of α2-adrenergic receptor may be etiologic importance in depression. To assess whether abnormalities presynaptic exist depressed patients not taking drugs, effects an α2agonist, clonidine, on plasma 3-methoxy-4-hydroxyphenelethyleneglycol (MHPG) and blood pressure (BP) were evaluated 15 12 healthy controls similar age. The ability clonidine to increase growth hormone (GH) secretion was also assessed. effect MHPG BP different between controls. However, GH response blunted patients. These results suggest depression (1) is abnormal, (2) postsynaptic adrenergic receptors decreased.
sci-hub.se 参考文章(41)
Dennis S. Charney, Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment Archives of General Psychiatry. ,vol. 38, pp. 1160- 1180 ,(1981) , 10.1001/ARCHPSYC.1981.01780350094011
J.N. Sharma, B.B. Sandrew, S.C. Wang, CNS site of clonidine induced hypotension: a microiontophoretic study of bulbar cardiovascular neurons. Brain Research. ,vol. 151, pp. 127- 133 ,(1978) , 10.1016/0006-8993(78)90955-1
Brian A. McMillen, Worthy Warnack, Dwight C. German, Parkhurst A. Shore, Effects of chronic desipramine treatment on rat brain noradrenergic responses to α-adrenergic drugs European Journal of Pharmacology. ,vol. 61, pp. 239- 246 ,(1980) , 10.1016/0014-2999(80)90126-0
Walter Kobinger, Ludwig Pichler, Centrally induced reduction in sympathetic tone — A postsynaptic α-adrenoceptor-stimulating action of imidazolines European Journal of Pharmacology. ,vol. 40, pp. 311- 320 ,(1976) , 10.1016/0014-2999(76)90068-6
Jesse M. Cedarbaum, George K. Aghajanian, Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the α-antagonist piperoxane Brain Research. ,vol. 112, pp. 413- 419 ,(1976) , 10.1016/0006-8993(76)90297-3
T. Svensson, T Usdin, Feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants: alpha-receptor mediation. Science. ,vol. 202, pp. 1089- 1091 ,(1978) , 10.1126/SCIENCE.213833
J.W. Maas, S.E. Hattox, D.H. Landis, R.H. Roth, The determination of a brain arteriovenous difference for 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) Brain Research. ,vol. 118, pp. 167- 173 ,(1976) , 10.1016/0006-8993(76)90854-4
H. Dekirmenjian, J. Maas, 3-methoxy-4-hydroxyphenethylene glycol in plasma Clinica Chimica Acta. ,vol. 52, pp. 203- 210 ,(1974) , 10.1016/0009-8981(74)90211-3
Ronald D. Robson, Michael J. Antonaccio, Jeffrey K. Saelens, Jeffrey Liebman, Antagonism by mianserin and classical α-adrenoceptor blocking drugs of some cardiovascular and behavioral effects of clonidine European Journal of Pharmacology. ,vol. 47, pp. 431- 442 ,(1978) , 10.1016/0014-2999(78)90124-3
G. Haeusler, Clonidine-induced inhibition of sympathetic nerve activity: no indication for a central presynaptic or an indirect sympathomimetic mode of action. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 286, pp. 97- 111 ,(1974) , 10.1007/BF00499107