Benchmark dose profiles for joint-action quantal data in quantitative risk assessment.

摘要: Benchmark analysis is a widely used tool in public health risk analysis. Therein, estimation of minimum exposure levels, called Doses (BMDs), that induce pre-specified Response (BMR) well understood for the case an adverse response to single stimulus. For cases where two agents are studied tandem, however, benchmark approach far less developed. This paper demonstrates how modeling paradigm can be expanded from single-dose setting joint-action, two-agent studies. Focus on outcomes expressed as proportions. Extending single-exposure setting, representations based joint-action dose-response model involving both agents. Based such model, concept profile (BMP) – two-dimensional analog BMD at which achieve specified BMR defined use quantitative characterization and assessment. The resulting, joint, low-dose guidelines improve planning regulation when dealing with low-level exposures combinations hazardous