Empirical evaluation of sufficient similarity in dose—Response for environmental risk assessment of chemical mixtures

摘要: When toxicity data are not available for a chemical mixture of concern, U.S. Environmental Protection Agency (EPA) guidelines allow risk assessment to be based on surrogate considered “sufficiently similar” in terms composition and component proportions. As supplementary approach, using statistical equivalence testing logic mixed model theory we have developed methodology define sufficient similarity dose—response mixtures many chemicals containing the same components with different ratios. Dose—response from 11 xenoestrogens endogenous hormone, 17s-estradiol used illustrate method.