The Role and Clinical Applications of Bioactive Lysolipids in Ovarian Cancer

摘要: OBJECTIVE: To review the current understanding of role bioactive lysolipids in ovarian cancer and their potential clinical applications. METHODS: A MEDLINE search our own work, including some unpublished are major sources review. The terms used included lysophosphatidic acid, lysophophatidylcholine (LPC), lysophosphatidylinositol (LPI), sphingosine-1-phosphate, sphingosylphosphorylcholine (SPC). RESULTS: Elevated lysolipid levels were detected plasma ascites samples from patients with compared healthy controls or nonmalignant disease. These regulate growth adhesion, production angiogenic factors, chemotherapeutic drug resistance cells, Ovarian cells likely to be at least one for elevated blood cancer. CONCLUSIONS: Bioactive might sensitive markers detecting gynecologic cancers, particularly prognostic value is worth further investigation, molecules can affect both proliferative metastatic potentials cells; therefore, regulation degradation these lipids interception interaction between receptors could provide novel useful preventative therapeutic measures.