Molecular characterization of the fibrinogen-erythrocyte interaction and its influence on cardiovascular pathologies by AFM-based force spectroscopy

摘要: IV important to prove if and how the concentration of this protein is involved in cardiovascular problem, order achieve a new type functional diagnosis. During experimental time project, thorough molecular study interactions between fibrinogen its specific erythrocyte membrane receptor was performed with two different approaches: i. A follow-up cardiac insufficiency patients etiologies: ischemic non-ischemic. Our results show that patient erythrocytes have highest binding force fibrinogen, indicating these represent group major risk. ii. chain mutant attached AFM tip intent studying interaction rodent erythrocytes. We understood more affected than platelets. Therefore, we suggest may be marker great importance characterization receptor, once it reveals erythrocyte’s decreases absence sequence. This data not only contributes prior goal characterizing for but also unveil effect on aggregation.