Reducing the number of fish in bioconcentration studies for plant protection products by reducing the number of test concentrations.
作者： Stuart Creton , Lennart Weltje , Hannah Hobson , James R. Wheeler
DOI: 10.1016/J.CHEMOSPHERE.2012.09.029
关键词:
摘要: Fish bioconcentration tests are time consuming, expensive, and use many animals. Alternative methods that replace, reduce or refine the of fish for BCF testing would therefore be value. Test guidelines generally require factors (BCFs) determined at two exposure concentrations. However, recent revisions to OECD Guideline (TG 305) provide option only one concentration, when justification is provided, although concentrations may still required some regulatory purposes. Analysis 55 studies on plant protection products demonstrates values do not significantly differ between This analysis provides evidence support revision TG 305, in particular using test concentration approach product active substances.
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sci-hub.se 参考文章(7)
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