Selective destruction of neurons by a transmitter agonist

作者: R. Herndon , J. Coyle

DOI: 10.1126/SCIENCE.197604

关键词:

摘要: Microinjection of nanomole amounts kainic acid, a heterocyclic analog glutamate, into the cerebellums adult hamsters and rats causes rapid degeneration Purkinje, basket, stellate, Golgi II cells, neurons that receive synaptic input from granule whereas cells themselves are spared. This selectivity is consistent with evidence glutamate cell transmitter supports hypothesis acid exerts its neurotoxic effects through receptors.

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