Principles in General Pharmacology

摘要: 1 General Principles: History and Overview.- Historical Perspective.- Principles.- Overview of Pharmacologic References.- 2 Dose-Effect Relations.- Graphs: Potency Efficacy.- Antagonists.- Quantal (All-or-None) Dose-Response Additivity Synergism.- 3 Pharmacokinetics.- Absorption.- Diffusion.- Rate Constant for Lipid-Water Partition Coefficient.- Transport Mechanisms.- Electrochemical Potential.- The Liver.- Drug Elimination.- Volume Distribution.- Clearance.- Drug-Protein Binding.- Protein Binding Disease.- Renal Excretion.- Glomerular Filtration.- Urine pH Hepatic Intravenous Dosing.- Repeated Injections.- Infusion.- Absorption Extravascular Multiple Time Course Effect Receptor Concentration.- 4 Metabolism (Biotransformation).- Anatomical Sites Biotransformation.- Biotransformation Reactions.- Factors Affecting Metabolism.- Biotransformations Selected Common Drugs.- 5 Introduction to Specific Action Membrane Surface Phenomena.- Nonspecific Action.- Action: Development the Concept Receptors.- Coated Pits Vesicles.- Capping.- Conclusion.- 6 Drugs Receptors: Chemical Bonding.- Types Bonds.- Bond Formation in Drug-Receptor Interaction.- Appendix A. Physical Constants.- B. Comparison Atomic, Ionic, Hydrated Radii Some Elements.- C. Structures Groups.- 7 Interactions.- Measuring Rates Equilibrium Influence Diffusion on Reaction Rate.- Suggested Reading.- 8 Pharmacodynamics: Interaction with Complex.- Classical Theory.- Alterations Theory Alternative Approaches.- Dissociation Combinations: Isoboles.- A Changing Concentration: Modification Equations.- 9 Radioligand Direct Analysis Subtypes.- Radioligand-Binding Techniques.- Appendix: Mathematical Tables.