Pretreatment C-reactive protein level predicts outcome and patterns of failure after chemoradiotherapy for locally advanced pancreatic cancer

摘要: Abstract Objectives In this study we evaluated the predictive value of pretreatment C-reactive protein (CRP) levels on patterns failure and survival outcomes in patients with locally advanced pancreatic cancer (LAPC) who received chemoradiotherapy (CRT). Methods Data from 65 underwent CRT for LAPC July 2001 to May 2013 were retrospectively collected. Factors, including age, gender, Eastern Cooperative Oncology Group performance status (PS), histological confirmation, tumor size, location, biliary drainage, stage, induction chemotherapy, CRP levels, neutrophil-to-lymphocyte ratio, platelet-lymphocyte albumin carbohydrate antigen 19-9, regard overall (OS) using a Cox proportional hazards model. Results The 1-year OS median follow-up all 63.9% 15.2 months, respectively. time 18.0 months 72.5%, respectively, lower (≤3.0 mg/L), whereas 11.0 30.8%, higher (>3.0 mg/L). Thirty-seven had recurrence after CRT. All developed distant metastases as primary sign treatment failure. multivariate analysis, significantly correlated disease-free (p = 0.004, HR = 4.50) HR = 3.001). By contrast, local progression-free was not different between subgroups. Conclusion significant predictor disease control