The effect of caffeine on two-stage skin carcinogenesis and on complete systemic carcinogenesis

摘要: A single large dose of caffeine (100 microgram/g body weight) was injected at different time in relation to urethan initiation for skin tumorigenesis, topical anthranil treatment serving as promotor. Caffeine significantly increased papilloma incidence when given 6 h before initiation, and an insignificant extent, 9 prior initiation. tendency inhibition evident administered after but this also not statistically significant. Lung adenoma induction by unaffected. The significance the timing modifying outcome phase is discussed.