Ochratoxin A and aristolochic acid involvement in nephropathies and associated urothelial tract tumours.
DOI: 10.2478/10004-1254-60-2009-2000
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摘要: This review addresses the unresolved aetiology of several nephropathies and associated upper tract tumours diagnosed all over world, but especially in Balkan regions. Studies conducted last 35 years point to mycotoxins, mainly ochratoxin A (OTA) as main culprit. Recent theories however have implicated aristolochic acids (AA). The aim this is put forward arguments favour mycotoxin theory show incoherence AA theory. It discusses differences between epidemiology endemic nephropathy (BEN) acid (AAN); OTA carcinogenicity; clinical pathological effects induced by AA; sources contamination (food, air, drinking water); OTA- AA-DNA adduct formation; role genetic polymorphisms; risk for young children.
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