Effects of Nitroglycerin and Nitroprusside on the Uterine Vasculature of Gravid Ewes

摘要: The effects of nitroglycerin (TNG) and sodium nitroprusside (SNP) on mean aortic pressure (MAP), uterine blood flow (UBF), vascular conductance (UVC), pulse rate (PR) were compared when the two agents infused to prevent treat hypertension induced by norepinephrine (NE) in gravid ewes. When alone, TNG, 19 microgram/kg/min, decreased MAP per cent increased PR 33 from control values (P less than 0.05), but did not significantly change UBF or UVC. In comparison, SNP, 3 20 43 given four successive 2-min infusions NE produced dose-related increase decreases UBF, UVC, PR; different with higher doses NE. Although MAP, UVC still changed levels was presence above TNG lower alone 0.05). a continuous infusion NE, SNP vasodilatation UBF. Nitroglycerin equally effective counteracting maternal antagonizing effect It is concluded that counteract vasoconstriction resulting alpha-adrenergic stimulation do produce shunt away vasculature used