An association between salivary gland disease and serological abnormalities in Sjogren's syndrome
作者： Seiji Nakamura , Akiko Ikebe-Hiroki , Masanori Shinohara , Yukiko Ohyama , Takefumi Mouri
DOI: 10.1111/J.1600-0714.1997.TB00243.X
关键词:
摘要: In the labial salivary glands (LSGs) of 16 primary and 18 secondary Sjogren's syndrome (SS) patients, infiltrating lymphocytes were histologically immunohistochemically examined; also, serum levels rheumatoid factor, antinuclear antibodies, anti-DNA anti-SS-A anti-SS-B immunoglobulins (including IgG, IgM IgA) all assayed. An immunohistochemical analysis lymphocyte subsets in LSGs revealed that severe lymphocytic infiltration was frequently accompanied by marked B cell accumulation both SS patients. Furthermore, local also closely associated with elevated antibodies this association statistically significant group but not SS. Thus, infiltration, especially accumulation, is suggested to be involved serological abnormalities SS, while complicated autoimmune diseases other than may
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