Continuous flow generation and reactions of anhydrous diazomethane using a Teflon AF-2400 tube-in-tube reactor.
作者： Federica Mastronardi , Bernhard Gutmann , C. Oliver Kappe
DOI: 10.1021/OL4027914
关键词:
摘要: A continuous process for generation, separation, and reactions of anhydrous diazomethane in a tube-in-tube reactor was developed. The inner tube the is made hydrophobic, gas-permeable Teflon AF-2400. formed then diffuses through permeable membrane into outer chamber subsequently reacts solution carried within. This technique allows safe scalable with dry to be performed on laboratory scale.
acs.org
core.ac.uk
sci-hub.se 参考文章(27)
Philippa B. Cranwell, Matthew O'Brien, Duncan L. Browne, Peter Koos, Anastasios Polyzos, Miguel Peña-López, Steven V. Ley, Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration Organic and Biomolecular Chemistry. ,vol. 10, pp. 5774- 5779 ,(2012) , 10.1039/C2OB25407G
Sean Newton, Steven V. Ley, Eva Casas Arcé, Damian M. Grainger, Asymmetric Homogeneous Hydrogenation in Flow using a Tube-in-Tube Reactor Advanced Synthesis & Catalysis. ,vol. 354, pp. 1805- 1812 ,(2012) , 10.1002/ADSC.201200073
Michael Struempel, Bernd Ondruschka, Annegret Stark, Continuous Production of the Diazomethane Precursor N-Methyl-N-nitroso-p-toluenesulfonamide: Batch Optimization and Transfer into a Microreactor Setup Organic Process Research & Development. ,vol. 13, pp. 1014- 1021 ,(2009) , 10.1021/OP900081G
Michael Struempel, Bernd Ondruschka, Ralf Daute, Annegret Stark, Making diazomethane accessible for R&D and industry : generation and direct conversion in a continuous micro-reactor set-up Green Chemistry. ,vol. 10, pp. 41- 43 ,(2008) , 10.1039/B710554A
Jaroslav Roh, Kateřina Vávrová, Alexandr Hrabálek, Synthesis and Functionalization of 5-Substituted Tetrazoles† European Journal of Organic Chemistry. ,vol. 2012, pp. 6101- 6118 ,(2012) , 10.1002/EJOC.201200469
EDWARD B. LEWINN, Diazomethane poisoning; report of a fatal case with autopsy. The American Journal of the Medical Sciences. ,vol. 218, pp. 556- 562 ,(1949) , 10.1097/00000441-194911000-00011
Farina Brackmann, Armin de Meijere, Natural Occurrence, Syntheses, and Applications of Cyclopropyl-Group-Containing α-Amino Acids. 1. 1-Aminocyclopropanecarboxylic Acid and Other 2,3-Methanoamino Acids Chemical Reviews. ,vol. 107, pp. 4493- 4537 ,(2007) , 10.1021/CR078376J
Lee D. Proctor, Antony J. Warr, Development of a Continuous Process for the Industrial Generation of Diazomethane1 Organic Process Research & Development. ,vol. 6, pp. 884- 892 ,(2002) , 10.1021/OP020049K
Jessamine Ng Lee, Cheolmin Park, George M. Whitesides, Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices. Analytical Chemistry. ,vol. 75, pp. 6544- 6554 ,(2003) , 10.1021/AC0346712