Effect of inhaled beclomethasone dipropionate on hypothalamic-pituitary-adrenal axis function in children with asthma.

摘要: The hypothalamic-pituitary-adrenal axis was investigated in 15 asthmatic children treated with inhaled beclomethasone dipropionate (mean 490 micrograms/day) and 11 control subjects receiving no corticosteroid therapy. Measurements of 24-h urinary free cortisol 17 hydroxy corticosteroids, serum cortisol, response to ACTH, the oral metyrapone test showed significant difference between two groups. All patients' results were within normal limits, carbohydrate metabolism, as shown by blood glucose hemoglobin A1c, not affected Thus, above dose, does cause suppression axis.