Application of N-carbamylglutamate in Rex rabbits to reduce body fat deposition and its possible mechanism.

摘要: N-Carbamylglutamate (NCG) has been shown to enhance arginine synthesis and improve growth performance in animals. However, the effect of NCG on body fat deposition remains unknown. This study examined effects evaluated potential mechanisms involved. Rex rabbits (3 months old) were assigned one four dietary groups supplemented with at following different concentrations a feeding trial that lasted 67 d: 0 (control), 0·04, 0·08, 0·12 %. supplementation increased serum proline by activating intestinal carbamoylphosphate synthase-І posttranscriptional level. Final weights not affected levels. NCG-treated had lower perirenal subcutaneous percentages, TAG content, hepatic fatty acid synthase (FAS) activity NO levels NO, hormone (GH), insulin-like factor 1 (IGF-1). There significant positive correlations between content percentage, as well FAS but negative levels, IGF-1 level after treatment. did affect health indicators, except for ammonia concentrations, which decreased rabbits. Our results suggest can serve supplement reduce unfavourable through inhibiting lipogenesis animals since it appears have no or health.