Interactions of the malaria parasite and its mammalian host.

摘要: A hallmark of Plasmodium development inside its mammalian victim is the remarkable restriction to host species. Adaptation an intracellular life style in specific target cells determined by multiple parasite-host interactions. The first line crosstalk occurs during intradermal sporozoite injection Anopheles mosquito. following expansion liver highly efficient and leads successful establishment parasite population. During periodic waves fevers chills destroys re-infects red blood cells. Recent advances experimental genetics imaging techniques begin expose complex interactions at changing interfaces. Understanding cellular molecular mechanisms cell recognition, nutrient acquisition, hijacking immune functions may ultimately explain elaborate biology a medically important single eukaryote.