Hypoxia promotes the proliferation of cervical carcinoma cells through stimulating the secretion of IL-8
作者： Li-Bing Liu , Feng Xie , Kai-Kai Chang , Ming-Qing Li , Yu-Han Meng
DOI:
关键词:
摘要: To explore whether hypoxia and interleukin 8 (IL-8) regulate the viability apoptosis of cervical carcinomas cells possible mechanism. We evaluated expression inducible factor-1α (HIF-1α), IL-8 its receptors (CXCR1 CXCR2) in cancer cervicitis tissues by immunohistochemistry. Then effects on HeLa SiHa were detected SRB assays. Here we observed that HIF-1α, CXCR1 was significantly higher than tissues. Hypoxic condition stimulated secretion CXCR2 cells. Recombinant human enhanced reduced cultured 1% oxygen showed increased apoptosis, former effect could be partly reversed anti-human neutralizing antibody. This data suggested secreted induced can stimulate an autocrine dependent manner, contribute to pathogenesis cancer.
参考文章(31)
Jeffrey E. Gershenwald, Reuven Reich, Menashe Bar-Eli, Suyun Huang, Mario Luca, Rakesh K. Singh, Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis American Journal of Pathology. ,vol. 151, pp. 1105- 1113 ,(1997)
Joost J Oppenheim, Teizo Yoshimura, Edward J Leonard, Kouji Matsushima, Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL 1). Journal of Immunology. ,vol. 139, pp. 788- 793 ,(1987)
William E Holmes, James Lee, Glenn C Rice, Wun-Jing Kuang, William I Wood, Structure and functional expression of a human interleukin-8 receptor. Science. 1991. 253: 1278-1280. Journal of Immunology. ,vol. 183, pp. 2895- 2897 ,(2009)
Petra van der Groep, A. Peter M. Heintz, Nicole Horrée, Paul J. van Diest, Daisy M. D. S. Sie-Go, Hypoxia and angiogenesis in endometrioid endometrial carcinogenesis. Analytical Cellular Pathology. ,vol. 29, pp. 219- 227 ,(2007) , 10.1155/2007/434731
Mohammad H Forouzanfar, Kyle J Foreman, Allyne M Delossantos, Rafael Lozano, Alan D Lopez, Christopher JL Murray, Mohsen Naghavi, None, Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis The Lancet. ,vol. 378, pp. 1461- 1484 ,(2011) , 10.1016/S0140-6736(11)61351-2
Dawei Ju, Dazhi Sun, Lijuan Xiu, Xianze Meng, Cian Zhang, Pinkang Wei, Interleukin-8 is associated with adhesion, migration and invasion in human gastric cancer SCG-7901 cells Medical Oncology. ,vol. 29, pp. 91- 99 ,(2012) , 10.1007/S12032-010-9780-0
Suhui Wu, Haixia Shang, Lihuan Cui, Zheng Zhang, Yanli Zhang, Ying Li, Jun Wu, Ren-Ke Li, Jun Xie, Targeted blockade of interleukin-8 abrogates its promotion of cervical cancer growth and metastasis Molecular and Cellular Biochemistry. ,vol. 375, pp. 69- 79 ,(2012) , 10.1007/S11010-012-1529-Y
Vera Mucaj, Jessica E. S. Shay, M. Celeste Simon, Effects of hypoxia and HIFs on cancer metabolism International Journal of Hematology. ,vol. 95, pp. 464- 470 ,(2012) , 10.1007/S12185-012-1070-5
Gregg L. Semenza, Targeting HIF-1 for cancer therapy Nature Reviews Cancer. ,vol. 3, pp. 721- 732 ,(2003) , 10.1038/NRC1187
Geza Acs, Paul J. Zhang, Cindy M. McGrath, Peter Acs, John McBroom, Ahmed Mohyeldin, Suzhen Liu, Huasheng Lu, Ajay Verma, Hypoxia-Inducible Erythropoietin Signaling in Squamous Dysplasia and Squamous Cell Carcinoma of the Uterine Cervix and Its Potential Role in Cervical Carcinogenesis and Tumor Progression American Journal of Pathology. ,vol. 162, pp. 1789- 1806 ,(2003) , 10.1016/S0002-9440(10)64314-3