Anti‐Inflammatory Property of n‐Hexadecanoic Acid: Structural Evidence and Kinetic Assessment
作者： Vasudevan Aparna , Kalarickal V. Dileep , Pradeep K. Mandal , Ponnuraj Karthe , Chittalakkottu Sadasivan
DOI: 10.1111/J.1747-0285.2012.01418.X
关键词:
摘要: Ester bond hydrolysis of membrane phospholipids by Phospholipase A2 and consequent release fatty acids are the initiating steps inflammation. It is proposed in this study that inhibition phospholipase one ways to control Investigations carried out identify mode n-hexadecanoic acid. may help designing specific inhibitors as anti-inflammatory agents. The enzyme kinetics proved acid inhibits a competitive manner. was identified from crystal structure at 2.5 A resolution position active site A2. binding constant energy have also been calculated using Isothermal Titration Calorimetry. Also, silico method compared with known inhibitors. be concluded structural studies acid, an inhibitor A2, hence, compound. inferences present validate rigorous use medicated oils rich for treatment rheumatic symptoms traditional medical system India, Ayurveda.
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