Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective.
作者： John R. Desjarlais , Greg A. Lazar , Eugene A. Zhukovsky , Seung Y. Chu
DOI: 10.1016/J.DRUDIS.2007.08.009
关键词:
摘要: A unique property of monoclonal antibodies, and a principal reason for their success as cancer therapeutics, is their ability to engage the immune system. A growing set of data …
elsevier.com
sci-hub.se 
researchgate.net 参考文章(98)
Nicole Selenko, Otto Majdic, Ulrich Jäger, Christian Sillaber, Johannes Stöckl, Walter Knapp, None, Cross-priming of cytotoxic T cells promoted by apoptosis-inducing tumor cell reactive antibodies? Journal of Clinical Immunology. ,vol. 22, pp. 124- 130 ,(2002) , 10.1023/A:1015463811683
Thomas Lehrnbecher, Charles B. Foster, Shaoxian Zhu, Susan F. Leitman, Lynn R. Goldin, Konrad Huppi, Stephen J. Chanock, Variant Genotypes of the Low-Affinity Fcγ Receptors in Two Control Populations and a Review of Low-Affinity Fcγ Receptor Polymorphisms in Control and Disease Populations Blood. ,vol. 94, pp. 4220- 4232 ,(1999) , 10.1182/BLOOD.V94.12.4220
Jeffrey W. Pollard, Tumour-educated macrophages promote tumour progression and metastasis Nature Reviews Cancer. ,vol. 4, pp. 71- 78 ,(2004) , 10.1038/NRC1256
Luminita Pricop, Patricia Redecha, Jean-Luc Teillaud, Jürgen Frey, Wolf H. Fridman, Catherine Sautès-Fridman, Jane E. Salmon, Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines. Journal of Immunology. ,vol. 166, pp. 531- 537 ,(2001) , 10.4049/JIMMUNOL.166.1.531
V. Groh, Y. Q. Li, D. Cioca, N. N. Hunder, W. Wang, S. R. Riddell, C. Yee, T. Spies, Efficient cross-priming of tumor antigen-specific T cells by dendritic cells sensitized with diverse anti-MICA opsonized tumor cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 6461- 6466 ,(2005) , 10.1073/PNAS.0501953102
Pablo Umaña, Joël Jean–Mairet, Radmila Moudry, Hanspeter Amstutz, James E. Bailey, Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity Nature Biotechnology. ,vol. 17, pp. 176- 180 ,(1999) , 10.1038/6179
Robert L Shields, Angela K Namenuk, Kyu Hong, Y Gloria Meng, Julie Rae, John Briggs, Dong Xie, Jadine Lai, Andrew Stadlen, Betty Li, Judith A Fox, Leonard G Presta, None, High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR Journal of Biological Chemistry. ,vol. 276, pp. 6591- 6604 ,(2001) , 10.1074/JBC.M009483200
William F. Dall’Acqua, Kimberly E. Cook, Melissa M. Damschroder, Robert M. Woods, Herren Wu, Modulation of the effector functions of a human IgG1 through engineering of its hinge region. Journal of Immunology. ,vol. 177, pp. 1129- 1138 ,(2006) , 10.4049/JIMMUNOL.177.2.1129
Francesco M. Marincola, Elizabeth M. Jaffee, Daniel J. Hicklin, Soldano Ferrone, Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Advances in Immunology. ,vol. 74, pp. 181- 273 ,(2000) , 10.1016/S0065-2776(08)60911-6
J C Edberg, R P Kimberly, Cell type-specific glycoforms of Fc gamma RIIIa (CD16): differential ligand binding. Journal of Immunology. ,vol. 159, pp. 3849- 3857 ,(1997)