Orthology: Definitions, Prediction, and Impact on Species Phylogeny Inference

摘要: Orthology is a central concept in evolutionary and comparative genomics, used to relate corresponding genes different species. In particular, orthologs are needed infer species trees. this chapter, we introduce the fundamental concepts of orthology relationships orthologous groups, including some non-trivial (and thus commonly misunderstood) implications. Next, review main methods resources identify orthologs. The final part chapter discusses impact on phylogeny inference, drawing lessons from several recent studies.