Plasma Interleukin-8 Concentrations Are Increased in Obese Subjects and Related to Fat Mass and Tumor Necrosis Factor-α System
作者： Marek Straczkowski , Stella Dzienis-Straczkowska , Agnieszka Stêpieñ , Irina Kowalska , Malgorzata Szelachowska
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摘要: Obesity is associated with the increased risk of cardiovascular disease; however, mechanisms responsible for such an increase are not fully understood. IL-8 a cytokine that might have atherogenic properties. Recent in vitro studies revealed produced and secreted by human adipocytes. The aim present study was to evaluate plasma concentrations obese subjects relationships between circulating anthropometric biochemical parameters TNF-α system. A total 75 normal glucose tolerance, 35 lean 40 obese, were recruited this study. Plasma levels measured fasting state, after oral tolerance test euglycemic hyperinsulinemic clamp. significant observed group. In simple regression analysis, performed initial evaluation relationships, related body mass index, percentage fat, fat (FM), soluble receptor 2 (sTNFR...
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endojournals.org参考文章(27)
Robert E. Gerszten, Eduardo A. Garcia-Zepeda, Yaw-Chyn Lim, Masayuki Yoshida, Han A. Ding, Michael A. Gimbrone, Andrew D. Luster, Francis W. Luscinskas, Anthony Rosenzweig, MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature. ,vol. 398, pp. 718- 723 ,(1999) , 10.1038/19546
Claire M. Steppan, Shannon T. Bailey, Savitha Bhat, Elizabeth J. Brown, Ronadip R. Banerjee, Christopher M. Wright, Hiralben R. Patel, Rexford S. Ahima, Mitchell A. Lazar, The hormone resistin links obesity to diabetes Nature. ,vol. 409, pp. 307- 312 ,(2001) , 10.1038/35053000
Gokhan S Hotamisligil, Peter Arner, Jose F Caro, Richard L Atkinson, Bruce M Spiegelman, Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. Journal of Clinical Investigation. ,vol. 95, pp. 2409- 2415 ,(1995) , 10.1172/JCI117936
Martine Moreau, Isabelle Brocheriou, Laure Petit, Ewa Ninio, M. John Chapman, Mustapha Rouis, Interleukin-8 mediates downregulation of tissue inhibitor of metalloproteinase-1 expression in cholesterol-loaded human macrophages : Relevance to stability of atherosclerotic plaque Circulation. ,vol. 99, pp. 420- 426 ,(1999) , 10.1161/01.CIR.99.3.420
J. Bruun, S. Pedersen, B. Richelsen, Interleukin-8 production in human adipose tissue. inhibitory effects of anti-diabetic compounds, the thiazolidinedione ciglitazone and the biguanide metformin. Hormone and Metabolic Research. ,vol. 32, pp. 537- 541 ,(2000) , 10.1055/S-2007-978682
Marek Str[aogon ]czkowski, Piotr Lewczuk, Stella Dzienis-Str[aogon ]czkowska, Irina Kowalska, Agnieszka St[ecedil]pie[nacute], Ida Kinalska, Elevated soluble intercellular adhesion molecule-1 levels in obesity: Relationship to insulin resistance and tumor necrosis factor-[alpha ] system activity Metabolism-clinical and Experimental. ,vol. 51, pp. 75- 78 ,(2002) , 10.1053/META.2002.28095
M. Urakaze, R. Temaru, A. Satou, K. Yamazaki, T. Hamazaki, M. Kobayashi, The IL-8 production in endothelial cells is stimulated by high glucose. Hormone and Metabolic Research. ,vol. 28, pp. 400- 401 ,(1996) , 10.1055/S-2007-979825
F. Hube, H. Hauner, The Role of TNF-α in Human Adipose Tissue: Prevention of Weight Gain at the Expense of Insulin Resistance? Hormone and Metabolic Research. ,vol. 31, pp. 626- 631 ,(1999) , 10.1055/S-2007-978810
Marco Baggiolini, Pius Loetscher, Bernhard Moser, Interleukin-8 and the chemokine family. International Journal of Immunopharmacology. ,vol. 17, pp. 103- 108 ,(1995) , 10.1016/0192-0561(94)00088-6
G. S. Hotamisligil, B. M. Spiegelman, Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes. ,vol. 43, pp. 1271- 1278 ,(1994) , 10.2337/DIAB.43.11.1271