Tumor angiogenesis in human lung adenocarcinoma.

摘要: BACKGROUND Hematogenous metastasis requires angiogenesis within the tumor. Previous studies have shown that microvessel counts in histologic sections of primary tumor, which reflect angiogenesis, are correlated with breast, prostate and Stage I nonsmall cell lung carcinoma. In this study, authors investigated association between hematogenous lymph node all stages adenocarcinoma. METHODS Microvessels were highlighted by immunostaining endothelial cells for factor VIII. We counted microvessels tumors 42 patients who had surgical resection (25 relapse 11 without more than 5 years after resection). Without knowledge patient outcome, on a 200x field (0.723 mm2) most active areas neovascularization. RESULTS The from (mean +/- standard deviation, 75.4 64.3) significantly higher those (42.6 26.0) (P = 0.027). Analysis regional metastases (factor N) revealed 62.6 35.1 N0 (no metastasis), 51.7 22.2 N1 (metastasis ipsilateral, peribronchial and/or ipsilateral hilar nodes, including direct extension), 75.3 N2 mediastinal subcarinal nodes), 74.0 N3 contralateral mediastinal, hilar, or scalene supraclavicular node[s]), these values not different each other. CONCLUSIONS Angiogenesis assessed counts, positively adenocarcinoma; there was no correlation